6th Annual Workshop: Instrumentation for Personalized Medicine
Center for Analytical Instrumentation Development
Purdue University September 23th and 24th 2013

Miniature Mass Spectrometry Analysis System for Direct Chemical Analysis

Aims:

Perform direct analysis of food, urine, and blood samples using a benchtop Mini MS system with simple operation procedures.

Instructors:

Linfan Li & Yue Ren

Instrumentation

Mini 12 Mass spectrometer with paper spray ionization

Experimental overview:

1. Simple sampling using capillaries coated with internal standard
2. Direct sampling ionization using paper spray sample cartridges
3. MS/MS analysis using rectilinear ion trap
4. Automated data processing providing direct quantitative results

What you will learn:

1. Design of a miniature MS system and its operation control for target applications
2. Methods of achieving high sensitivity with Mini MS and ambient ionization methods

Additional applications:

Direct complex mixture analysis in therapeutic drug monitoring (blood), food safety, environmental monitoring, and point-of-care biofluid diagnostics.